Results from a substudy of the ODYSSEY trial show that children being treated for tuberculosis (TB) and HIV at the same time can safely have the anti-HIV medicine dolutegravir twice a day. These results were published yesterday in The Lancet HIV journal. Around 50,000...
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ResultsBorrowing information across patient subgroups in clinical trials, with application to a paediatric trial
Authors: R.M. Turner, A Turkova, C.L. Moore, A Bamford, M Archary, L.N. Barlow-Mosha, M.F. Cotton, T.R. Cressey, E Kaudha, A Lugemwa, H Lyall, H.A. Mujuru, V Mulenga, V Musiime, P Rojo, G Tudor-Williams, S.B. Welch, D.M. Gibb, D Ford, I.R. White & and the ODYSSEY...
Dolutegravir dosing for children with HIV weighing less than 20 kg: pharmacokinetic and safety substudies nested in the open-label, multicentre, randomised, non-inferiority ODYSSEY trial
Authors: H Waalewijn, M.K Chan, P.D.J Bollen, H.A Mujuru, S Makumbi, A.R Kekitiinwa, E Kaudha, T Sarfati, G Musoro, A Nanduudu, A Lugemwa, P Amuge, C.L Moore, P Rojo, C Giaquinto, A Colbers, D.M Gibb, D Ford, A Turkova, D.M Burger Published in: The Lancet HIV ...
Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children
Authors: A Turkova, E White, HA. Mujuru, AR. Kekitiinwa, CM. Kityo, A Violari, A Lugemwa, TR. Cressey, P Musoke, E Variava, MF. Cotton, M Archary, et al for the ODYSSEY Trial Team Published in: The New England Journal of Medicine Read
Easy-to-take medicine better at suppressing HIV in children
A once-a-day antiretroviral medicine that is low-cost and easy for children to take is also more effective at suppressing HIV than standard treatments, according to a global trial led by researchers at UCL.
Dolutegravir-based ART is superior to standard of care ART in young children <14kg living with HIV
Authors: Kaudha E On behalf of the ODYSSEY trial Presented at: PEPFAR Uganda Science Summit Read
ODYSSEY trial wins 2021 Hector Award
It was announced at the 8th European AIDS Conference that the laureates of the Hector Research Award in HIV 2021 in clinical and/or epidemiological science was received Angela Colbers and David Burger on behalf of the ODYSSEY trial team! The winning paper Simplified...
Dolutegravir-Based ART is Superior to Standard of Care in Young Children Living With HIV (combined results of the main trial and the ‘under 14kg’ cohort)
Authors: Anna Turkova on behalf of the ODYSSEY trial team Presented at: CHIVA 2021 (Oral presentation) Download
Dolutegravir-based ART is superior to NNRTI- and PI-based ART in infants, children and adolescents living with HIV(combined results of the main trial and the ‘under 14kg’ cohort)
Authors: Turkova A on behalf of the ODYSSEY trial team Presented at: CHIVA 2021 Read
Virological failures and genotypic resistance in children and adolescents randomised to dolutegravir-based ART vs. standard-of-care in the main ODYSSEY trial (≥14kg)
Authors: White E and Kityo C on behalf of the ODYSSEY trial team Presented at: CHIVA 2021 Read

